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BAGHDAD - Bombs striking Shiite neighbourhoods, security forces and other targets across Iraq killed at least 26 people Sunday, officials said. It was the latest instance in which insurgents launched co-ordinate attacks in multiple cities across the country in a single day, apparently intending to rekindle widespread sectarian conflict and undermine public confidence in the beleaguered government.
The deadliest attack came in the town of Taji, a former al-Qaida stronghold just north of Baghdad, where three explosive-rigged cars went off within minutes of each other. Police said eight people died and 28 were injured in the back-to-back blasts that began around 7:15 a.m.
In all, at least 94 people were wounded in the wave of attacks that stretched from the restive but oil-rich city of Kirkuk in Iraq's north to the southern Shiite town of Kut.
There was no immediate claim of responsibility for the violence, but car bombs are a hallmark of al-Qaida in Iraq. The Sunni militant network has vowed to take back areas of the country, like Taji, from which it was pushed before U.S. troops withdrew last December.
Shortly after the Taji attacks, police said a suicide bomber set off his explosives-packed car in the Shiite neighbourhood of Shula in northwest Baghdad. One person was killed and seven wounded. Police could not immediately identify the target.
"So many people were hurt. A leg of a person was amputated," lamented Shula resident Naeem Frieh. "What have those innocent people done to deserve this?"
And in Baghdad's bustling Karrada neighbourhood, a parked car laden with explosives went off next to a police patrol, killing a police officer and a civilian, other officials said. Eight other people were injured. The blast was followed minutes later by another parked car bomb as people gathered, killing three civilians and injuring 12 others, they added. Secondary bomb blasts targeting those coming to help the wounded are a common insurgent tactic.
Elsewhere in the country, another suicide bomber drove a minibus into a security checkpoint in Kut, located 160 kilometres (100 miles) southeast of Baghdad. Three police officers were killed and five wounded, Maj. Gen. Hussein Abdul-Hadi Mahbob said.
And in Iraq's north, another policeman was killed when security forces were trying to defuse a car bomb parked on the main highway between the cities of Kirkuk and Tuz Khormato, said Kirkuk police chief Brig. Gen. Sarhad Qadir. A second policeman was wounded in the blast, Qadir said. Kirkuk is about 290 kilometres (180 miles) north of Baghdad.
In mid-morning, another parked car bomb went off next to a bus carrying Iranian pilgrims in the town of Madain, killing three Iraqis and injuring 11 others included seven Iranians, another police officer and health official said. Madain is a mainly Sunni area located 20 kilometres (12 miles) southeast of Baghdad.
In the town of Balad Ruz, 75 kilometres (45 miles) northeast of Baghdad, a parked car bomb targeted a passing police patrol, killing two policemen and injuring seven others, a police officer and health official said. And in the nearby town of Khan Bani Saad, 15 kilometres (nine miles) northeast of Baghdad, yet another parked car bomb exploded near a market and killed one civilian and injured nine others, they added.
Two Iraqi soldiers were killed in the town of Tarmiyah, 50 kilometres (30 miles) north of Baghdad, when their patrol hit a roadside bomb, another police officer and health official said. Six other people, including four civilians were wounded.
Health officials in Taji, Tarmiyah and Baghdad confirmed the casualties. All officials spoke anonymously as they were not authorized to release information.
Violence has dropped since the height of Iraq's bloodshed a few years ago, but Iraqi forces have failed to stop the attacks that continue to claim lives almost daily.
Senior central government officials were not available for comment.
Source: http://news.yahoo.com/bombs-target-shiite-areas-security-forces-multiple-cities-131016590.html
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Tampa?? More than most students milling about the hallway at the Davis Conference Center at MacDill Air Force Base, Caleb Allen knows the cost of war. His father, retired Marine Cpl. Mike Jernigan, was blinded when his Humvee hit an improvised explosive device while on patrol in Iraq in 2004. But that didn't stop...
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Source: http://www.msnbc.msn.com/id/49224676/ns/local_news-tampa_fl/
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Welcome to Beneath My Heart! I am so glad you are here. If you like DIY projects, decorating on a dime, and frugal living, you've come to the right place. Join me as I try to create beauty in my heart and in my home. If you enjoy your visit, I hope you will want to subscribe to my RSS feed Thanks for visiting!
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Hey Friends!
I am going to start the party a day early since it falls on the weekend.
Have you had a busy September?
I feel like we have finally made it to the top of our ?renovation? hill, and we are headed down the other side.? The bulk of the mess is over, and we can start working on the little details.? (Well, except for the boys? rooms upstairs, but let?s not talk about that right now, K?)
My favorite project of September was definitely the dresser I painted with Annie Sloan Chalk paint.? I am still crazy about it!
You can read about that project HERE, or click on the picture.
?
So what have you been up to?? I can?t wait to see it!
Please remember to follow the party guidelines:
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Thanks for coming to my party!
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A beautiful home with wooden flooring is the common answer you will get when asking someone about their dream home. This is why, most new homeowner will go straight to the wood flooring options when they have the chance to select their own flooring solution. If you are one of those new homeowners, it will be better for you to stop a while and gather as much information as possible so you will be able to make the right choice.
Flooring solutions are not cheap, and wood flooring is no exception. You will have to spend a lot of money on it so make sure that you will be able to enjoy the most of it. Not only the satisfaction, but also the low maintenance as a positive value you need to consider. The quality is an important aspect, but don?t forget to consider the specific design to achieve your desired home style.
For those who need more information source, the Cunninghamsflooringofardmore.com have a lot of recommendation you should check during the assessment process. From the different types of wooden flooring up to the wooden flooring installation process, all are explained briefly in order to give you more perspective during the process of selecting the best flooring solution.
This entry was posted on Friday, September 28th, 2012 at 2:20 am and is filed under General. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
Source: http://www.hawkeyevillage.com/wooden-flooring-for-your-dream-home
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Royal Bank of Scotland has priced and placed ?290m of the outstanding ?463m Project Isobel debt this afternoon in the first European securitisation of a loan secured by a commercial property loan portfolio in almost six years.
RBS has securitised the outstanding balance of the original ?553m four-year loan extended to the special purpose vehicle which owns the underlying 37 commercial property balance sheet loans, which remains owned 75% by RBS and 25% by Blackstone.
The three-class Isobel Finance transaction comprises:
Standard & Poor?s was the sole rating agency, while RBS acted as sole bookrunner and lead arranger.
The legal final maturity of Isobel Finance is 17 October 2038, an estimated six year tail-period following the longest of the underlying Project Isobel?s 25-year dated interest rate swaps.
RBS placed all the AAAs and AAs and, except for the 5% retention requirements under European Commission?s Capital Requirements Directive (CRD) regulations, with a small number of traditional CMBS bond buyers, dubbed ?real money investors?.
Separately, RBS today has listed ?340.9m in junior notes on the Channel Islands this afternoon, which is essentially RBS and Blackstone?s joint equity holding in the form of tradeable junior notes.
This puts Blackstone?s original equity at ?85.225m, while RBS? equity was ?255.675m.
In addition to the ?553m four-year senior loan, priced at 450 bps over three-month LIBOR with a one-year extension option, puts the original discount agreed for the Project Isobel loan portfolio at 34.3%, based on a price of ?893.9m against a nominal of ?1.36bn, according to CoStar News calculations.
The original LTV of RBS? loan-on-loan financing was 61.8%.
Together with the unplaced ?173m BBB+-rated class Cs, RBS has now structured the equity and debt capital stack providing the bank with flexibility to trade either the unmarketed bonds or divest some of its 75% equity stake.
RBS has no current plans to sell either but considers these options to be strategically useful for the remaining working out of the underlying loan and real estate portfolio.
Prior to the final closing of Project Isobel with Blackstone in December last year, RBS decided not to take-up third party financing because the bank believed that the 550 basis points quoted margins was disproportionately high pricing for such an ultimately fast-amortising loan.
Lloyds Banking Group?s Projects Royal and Harrogate, traded to Lone Star and Oaktree Capital Management respectively, are both financed by short-term loans priced around 600 bps over three month LIBOR. ?Oaktree?s JPMorgan loan for Harrogate is thought to be less than 18 months.
The ?553m provided in stapled financing was priced at around 100 bps lower by RBS than could be achieved externally, with this lower cost of capital enabling superior returns to both itself and Blackstone.
It remains to be seen whether RBS? successful placing of ?290m worth of bonds secured by the Project Isobel sub and non-performing loan portfolio encourages a wider adoption of NPL securitisations in Europe, given an apparent trade-off between the lower cost of capital achieved with the time taken to close the partial capital markets exit.
The last securitisation of an NPL was Bluebonnet Finance in December 2006, which was of a ?2.8bn portfolio of former Hypo Real Estate German commercial and multifamily loans bought buy Lone Star?s Fund V in November 2004 with acquisition finance from Citigroup.
jwallace@costar.co.uk
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Source: http://costarfinance.wordpress.com/2012/09/28/rbs-prices-463m-isobel-finance-today-and-places-290m/
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(13.05.2012) -- The sporty and elegant design of the new three-door model, along with additional engine choices, are distinguishing features that sharpen the unmistakable profile of the BMW 1 Series as the recognised standard of sheer driving pleasure in the premium compact car segment. Powerful petrol and diesel engines with BMW TwinPower Turbo technology, the latest chassis design and rear-wheel drive, which is unique for a vehicle in this class, guarantee a sporty driving experience which is reflected in the dynamic and lean appearance of the new three-door BMW 1 Series.
Summary
- Second body variant added to the new BMW 1 Series; Latest edition of the three-door version impressively underscores the compact model's sporting characteristics; Sporty, elegant design and attractive supplements to the drive portfolio strengthen the BMW Series' unsurpassed position within the segment characterised by the unique rear-wheel drive system and superior handling; Highlight in the model range: the BMW M135i.
- New three-door BMW 1 Series with powerful, brand-typical proportions; Unique appearance thanks to dynamically stretched side line; Wide doors with frameless windows; Side window graphics flowing seamlessly into the B pillar and strongly retracted side window graphics; powerfully contoured side panels with particularly distinctive accentuation of the rear wheel arches; Side sill line extending to the front, underscoring the dynamically stretched character of the vehicle's silhouette.
- Precise individualisation thanks to BMW Sport Line, BMW Urban Line and M Sport Package; Harmoniously matching, exclusive design and equipment features as an alternative to the basic variant; BMW M135i with model-specific exterior and interior design directly attuned to the technical requirements.
- Interior features, sporty appearance and handling profit from increased body length (+85 millimetres), wheelbase (+30 millimetres), track width (front: + 51, rear +72 millimetres) and width (+17 millimetres) in comparison to the predecessor model, with vehicle height remaining the same; Choice of two or three seats respectively at the rear, 21 millimetres more legroom at the rear, luggage compartment increased by 30 litres to 360 litres; Storage capacity of up to 1 200 litres thanks to foldable rear seat back (40 : 20 : 40 split folding optional).
Widened choice of petrol and diesel engines featuring BMW TwinPower Turbo technology; BMW 114i as new entry-level version with 75 kW/102 hp; Also available at market launch:
- BMW 116i (100 kW/136 hp), BMW 125i (160 kW/218 hp),
- BMW 116d (85 kW/116 hp), BMW 118d (105 kW/143 hp) and the
- BMW 125d (160 kW/218 hp) and the BMW 116d EfficientDynamics Edition with 85 kW/116 hp, additional fuel efficiency measures and a CO2 emissions level of 99 g/km in the EU test cycle.
- First ever BMW M Performance automobile to feature a petrol engine: BMW M135i with a 3-litre, straight six-cylinder engine and 235 kW/320 hp as well as M-characteristic suspension components and aerodynamically optimised body features; Highest level of performance and the most outstanding efficiency within the competitive environment; Typical M-style coherence between drive, suspension technology and aerodynamic balance as well as model-specific interior design for unmistakeable driving pleasure in a compact model; BMW M135i also available as a five-door version.
Also available from November 2012:
- BMW 118i (125 kW/170 hp),
- BMW 120d (135 kW/184 hp) as well as intelligent four-wheel drive
- BMW xDrive featured for the first time in the BMW 1 Series on the models BMW M135i xDrive and BMW 120d xDrive; BMW xDrive simultaneously available also for the 5-door version of the
- BMW 1 Series.
- All engine variants come with optimised six-speed manual transmissions as standard; Unique option in the compact segment: eight-speed automatic transmission or eight-speed automatic sports transmission; Comprehensive use of BMW EfficientDynamics technology including Auto Start Stop function in conjunction with manual and automatic transmissions as well as ECO PRO mode, which can be activated in conjunction with the Driving Experience Control function offered as standard.
- Vehicle concept perfectly attuned to driving pleasure, with longitudinally mounted engines, rear-wheel drive, harmonious weight distribution and sophisticated suspension technology; Best agility in the segment combined with optimised riding comfort; Double-joint spring-strut front axle, five-link rear axle; Exceptionally precise electromechanical power steering free from drive train influences; Variable sports steering as an option; DSC Dynamic Stability Control including DTC and Active Differential Brake (ADB-Sport) on the rear axle as standard; Torsion-resistant body structure; Comprehensive safety features.
- Optimised premium interior ambience thanks to excellent material quality and craftsmanship; Interior with driver-oriented cockpit; Control display of the optional operating system iDrive fitted as a firmly integrated onboard monitor sporting an exclusive BMW flat screen design.
- Wide range of driver assistant systems and mobility services from BMW ConnectedDrive that are unique in the compact segment: High-Beam Assistant, Adaptive Headlights, Rear View Camera, Lane Departure Warning incl. Rear Collision Warning, Parking Assistant, Cruise Control with braking function, Speed Limit Info with No Passing Indicator, Internet access, enhanced integration of smartphones and music players, Real-Time Traffic Information and Apps for personalised web radio reception and for access to Facebook and Twitter.
Specifications. The new BMW 1 Series 5 Door Hatch. M135i
Body
No. of doors/seats: 5 / 5
L/W/H1 (unladen) mm: 4340 / 1765 / 1411
Wheelbase mm: 2690
Front/rear track mm: 1512 / 1532
Ground clearance mm: 130
Turning circle m: 10.9
Fuel capacity approx. l: 52
Cooling and heating system reservoir capacity l: 6.7 (7.2)
Engine oil capacity2 l: 6.5
Weight, unladen (DIN/EU) kg: 1430 / 1505 (1445 / 1520)
Payload (DIN) kg: 530
Permitted total weight kg: 1960 (1975)
Permitted axle load, front/rear kg: 950 (960) / 1110
Permitted trailer load (12%) braked/unbraked kg: ? / ?
Permitted roof load/trailer download kg: 75 / ?
Luggage compartment capacity l: 360 ? 1200
Aerodynamic drag cc x A: 0.33 x 2.14
Engine
Type/no. of cylinders/valves: in-line / 6 / 4
Engine technology: M TwinPower Turbo technology with twin-scroll turbocharger, High Precision Injection, VALVETRONIC fully variable valve control and Double-VANOS variable camshaft control
Effective capacity cc: 2979
Stroke/bore mm: 89.6 / 84.0
Compression ratio :1 10.2
Fuel type: min. RON 91
Output kW/hp: 235 / 320
at rpm min?1: 5800
Torque (with overboost) Nm: 450
at rpm min?1: 1250?5000
Electrical
Battery charge/location Ah/?: 80 / luggage compartment
Alternator current/output A/W: 210 / 2940
Driving Dynamics and Safety
Front suspension: Aluminium double-joint cross-strut axle with M-specific elastokinematics
Rear suspension: Lightweight steel five-link with double elastic bearing
Front brakes: Four-piston swing-calliper disc brakes
Diameter mm: 3/air-cooled
Rear brakes: Two-piston swing-calliper disc brakes
Diameter mm: 3/air-cooled
Driving stability systems - As standard: DSC inc. ABS, ASC and DTC (Dynamic Traction Control), CBC Cornering Brake Control, DBC Dynamic Brake Control, brake drying function, fading compensation, hill assist
Safety equipment - As standard: driver and front-seat passenger airbags, driver and front-seat passenger side airbags, front and rear head airbags, three-point automatic seatbelts for all seats, seatbelt tensioners and seatbelt force limiters in front seats, crash sensors, tyre pressure warning
Steering: Electromechanical power steering (EPS), Variable Sport Steering
Overall steering ratio :1 15.0
Front/rear tyres: 225/40 R18 88Y/ 245/35 R18 88Y
Front/rear wheels: 7.5J x 18 light-alloy/ 8J x 18 light-alloy
BMW ConnectedDrive
Comfort - Optional: BMW Assist including information service, remote functions, Real Time Traffic Information, BMW TeleServices, mobile device integration
Information and entertainment - Optional: Internet connectivity, BMW Online including parking information, country information, Google business search, news, real-time weather, BMW Routes, office functions, Bluetooth audio streaming, online music title update, apps
Safety - Optional: Adaptive Headlights with turning lights, variable light distribution, Adaptive Headlight range adjustment, high beam assistance, park distance control, reversing camera, cruise control with brake function, parking assistant, Lane Departure Warning with Collision Warning, speed limit and no passing information, extended emergency call
Transmission
Type of gearbox: 6-speed manual (optional: 8-speed automatic with Steptronic)
Gear ratios I :1 4.110 (4.714)
II :1 2.315 (3.143)
III :1 1.542 (2.106)
IV :1 1.179 (1.667)
V :1 1.000 (1.285)
VI :1 0.846 (1.000)
VII :1 ? (0.839)
VIII :1 ? (0.667)
R :1 3.727 (3.295)
Differential ratio
:1 3.077 (3.077)
Performance
Weight-to-power ratio (DIN) - kg/kW: 6.1 (6.1)
Specific power output - kW/l: 78.9
Acceleration
0?100 km/h sec.: 5.1 (4.9)
0?1,000 m sec.: 23.9 (23.8)
in 4th/5th gear 80?120 km/h sec.: 4.3 / 5.0
Max. speed km/h: 250 (250)
BMW EfficientDynamics - BMW EfficientDynamics Features included as standard: Brake Energy Regeneration, electromechanical power steering, Automatic Start/Stop function, gear shift indicator (manual), ECO PRO mode, intelligent lightweight construction, automatically disconnecting ancillary components, map-regulated oil pump, differential with optimized-warm-up behaviour, tyres with reduced rolling resistance
Fuel consumption (EU)
Urban l/100 km: 11.2 (10.3)
Extra-urban l/100 km: 6.2 (5.8)
Total l/100 km: 8.0 (7.5)
CO2 emissions g/km: 188 (175)
Emissions standard EU5
Source: http://www.autoblog.com/2012/09/27/2013-bmw-m135i-xdrive-paris-2012/
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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/_5iLdOQsLZo/18-places-carbon-fiber-doesnt-belong
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Foster parents Bobby, right, and Johhny, left, with Jada, Chase and Joseph
Bobby?s day usually begins around six in the morning, preparing meals and getting the children and her husband, Johnny, ready for their day. To say her home is a whirlwind of activity for most of the day is an understatement.
For Bobby and Johnny, it?s a mission of sorts. They both had children from previous marriages, but their union was more than a simple marriage. It was the grand opening of their home.
?It wasn?t like ?those are your kids and these are mine,?? Johnny said. ?It?s all of us together. We?re all in it together.?
During the past four years, they?ve opened their home to more than 10 foster children, recently adopting three ? Chase, 15; Jada, 8; and Joseph, 3. Both coming from abusive and neglectful childhoods, Bobby and Johnny decided their home was going to be a haven, a safe place for children who needed attention, care and love.
?I?ve always wanted to protect abused children,? Bobby said. ?I wanted to help children who?ve been mistreated.?
Chase was removed from his home because of abuse and neglect. He was also physically and verbally aggressive. His first foster placement didn?t work well, but Bobby and Johnny were patient and Chase slowly transformed. He?s part of the family, and helps care for his younger sister and brother.
Joseph was born to a drug-addicted mother. He cried and wailed incessantly while his body weaned itself from the narcotics. He had to be soothed and held constantly. His sleep was erratic. Bobby and Johnny never wavered.
?We just held him and loved him,? Johnny said. ?There wasn?t anything else we could do.?
There are no signs of those troubles now, as Joseph and his freshly cut Mohawk hairdo speed from room to room and down the hallway with his sister. He laughs and plays just like any other 3-year-old boy.
Bobby runs children to doctor?s appointments and other things. In addition to the adopted children, they?re still foster parents to three other children. She calls them all by pet names and maintains an unending supply of affection and energy. To nearly everyone who goes in and out their front door, they?re called Mamaw and Papaw. But there are still standards.
?Oh yes, we?ve got rules,? Bobby said. ?We expect good grades in school, manners, and being respectful of adults and other children. They all have chores to do to help around the house. We expect them to mind.?
The children?s bedtime is usually around 8 in the evening. Bobby and Johnny end the evening cleaning and straightening up the circus of the previous 14 hours.
Most days, Bobby?s evening continues through to the wee hours of the next day.
?Having foster children is like this: It?s a lot of news, and it can be bad one day, good the next day and then great another day,? she said. ?It?s a lot of work and you have to be flexible. But we love all of them. It?s difficult sometimes when they leave ? you want them to go home to their families, but you get attached and you?re sad to see them leave.?
And then the next morning begins the daily routine. Bobby and Johnny said they?d take in more children if they could.
The children are safe. They?re loved. Most important, they?re happy.
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Source: http://youthvillages.wordpress.com/2012/09/26/the-joyful-labors-of-a-very-happy-home/
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What does a Marine Finance Company do?
Here are some examples:-
It can provide marine finance in the small boat market with loans up to about ?50,000, probably using a fixed rate of interest, over a period of maybe 5 years.
- For larger boats, with loans exceeding ?50,000, the facility is usually a variable rate and is usually over a period from 5 to 10 years.
- It can help you to refinance your existing boat by providing funds to cover an expensive overhaul, new engine or some other large bill.
- A mortgage on the vessel is normally required for all of these loans. If you live in the UK you may find it easier to obtain a loan if you register your boat on the Small Ships Register (SSR).
There are many specialist marine finance companies and it is worth while examining them carefully for the deal that suits your requirements best. They will have helpful and informative websites and will give you free quotations according to your requirements, but on the whole the procedures will be similar.
- First you need to find out the money you need to contribute, the deposit, the interest rates, terms and small print.
- Next you will have to be "approved" by filling in a "loan application", "finance application" or "credit application" in which you will provide information about yourself and confirm that you have the wherewithal to pay the loan back. The sort of details you will need to provide are proof of income, credit information and some personal information about you and your family, such as where you live and how long you have lived there. They will also want to know what you want to do with your boat; whether it is for recreation, racing, to live on, or a business venture.
- Usually the deal can be completed in a day or so.
The documents you will need consist of a marine mortgage document, which is the loan agreement, and a standing order with your bank to transfer the agreed monthly payment. For a new boat, the finance company will require the original invoice or bill of sale from the boat builder to you. If it is a used boat that you are purchasing you will need a bill of sale to be completed by the current owner of the boat agreeing to sell the boat to you and possibly a survey, depending on the age, value and type of boat.
You must have your boat comprehensively insured.
What types of payment plan are currently available?
- Balanced Payment Plan - This is the most popular. Monthly payments are fixed and stay the same for the entire period.
- Deferred "Balloon" Payment Plan - The monthly payment is reduced by deferring some of the mortgage to the end of the finance term. It is an attractive proposition if you plan to sell your boat before the payment is due.
- Low Start Payment Plan - There are lower monthly payments in the early stages, with annual increases in the following years.
- Variable Rate Payment Plan - These are linked to a bank base rate so that repayments move up and down according to fluctuations in the interest rate.
- Tailored Loans - These plans are tailored to fit individual cash flow requirements.
When making a big decision on taking out a loan to finance your boat, the best advice is, first arm yourself with the basic ins and outs of marine finance as shown above and then shop around until you have found a friendly and reliable finance company who will provide you with a package that suits your needs. And do remember to read all the small print.
Happy hunting!
Source: http://www.artipot.com/articles/1386638/a-basic-guide-to-marine-finance.htm
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ScienceDaily (Sep. 25, 2012) ? An evolutionary biologist at The University of Manchester, working with scientists in the United States, has found compelling evidence that parts of the brain can evolve independently from each other. It's hoped the findings will significantly advance our understanding of the brain.
The unique 15-year study with researchers at the University of Tennessee and Harvard Medical School also identified several genetic loci that control the size of different brain parts.
The aim of the research was to find out if different parts of the brain can respond independently of each other to evolutionary stimulus (mosaic evolution) or whether the brain responds as a whole (concerted evolution). Unlike previous studies the researchers compared the brain measurements within just one species. The findings have been published in the journal Nature Communications.
The brains of approximately 10,000 mice were analysed. Seven individual parts of each brain were measured by volume and weight. The entire genome, except the Y chromosome, was scanned for each animal and the gene set for each brain part identified.
Dr Reinmar Hager from the Faculty of Life Sciences compared variation in the size of the brain parts to variation in the genes. He found that the variation in the size of brain parts is controlled by the specific gene set for that brain part and not a shared set of genes.
He also compared the measurements for each mouse to the overall size of its brain. Surprisingly he found very little correlation between the sizes of the brain parts and the overall size of the brain.
Dr Hager says: "If all the different brain parts evolved as a whole we would expect that the same set of genes influences size in all parts. However, we found many gene variations for each different part of the brain supporting a mosaic scenario of brain evolution. We also found very little correlation between the size of the brain parts and the overall size of the brain. This again supports the mosaic evolutionary hypothesis."
Using the data collected from the mice Dr Hager and colleagues analysed the genes that influence the size of the brain to the genes that control the size of the body. They wanted to find out how independent size regulation of the brain is to that of the body.
They found evidence that the size of the brain is governed by an independent gene set to the one that controls the size of the body. Again they found vey little correlation between variations in the size of the body and the brain.
The evidence means that overall brain size can evolve independently of body size.
Following this research more work will be carried out to identify the specific genes that underlie the size of different parts in the brain
Dr Hager says: "If we can identify the specific genes that cause variations in the size of brain parts then there will be big implications for researchers looking at neuronal disease and brain development. We hope this research will significantly advance our understanding of the brain."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/OH7hUBzLW5I/120926094544.htm
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President Barack Obama's re-election campaign said Wednesday that recent polls have shown Mitt Romney's path to the White House "narrowing" but flatly denied that it was spiking the ball on the 30-yard line.
"We're running this race in every single swing state like we're five points down," campaign spokeswoman Jen Psaki told reporters.
The Obama campaign isn't known for its bashfulness or self-doubt, but aides have long dismissed public polls. They pre-emptively scoffed at future surveys showing the president with a "bump" after the convention and have always said they expect a tight race to the finish. At the same time, aides have had an unmistakable spring in their step of late as polls in pivotal states like Ohio show their guy with an edge.
"I will say that as time progresses, the field is looking like it's narrowing for them," Psaki said.?"And so, in that sense, we'd rather be us than them, because we want a field?or a path, I should say?where you can drive a Mack truck through it, not one where you can drive a little scooter through it." (Yes, Psaki is aware that she's mixing metaphors. She's funny. Trust me.)
Her comments came as both Obama and Romney campaigned in Ohio. No Republican has won the White House without carrying the Buckeye State, and the president leads here according to several recent polls. The Democrat's campaign highlighted that early voting in Ohio starts next week.
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It amazes me sometimes just all the people who were part of the fraud when it comes to online business, and this brings me to another point that I want to talk with you. You see, in the form of prolific online article writer who wrote a series of articles on the subject of internet business activity. I would argue that more writers to prepare articles of quality content online about this, some people are, by nature, ethics and busy copying what others are doing in their online business that may be unethical to prevent worsening of the problem.
You see, if more people from home business online, however, there will be more customers because people feel more comfortable doing business on the internet. At the time people were quite simple, and buy the best e-commerce sites, they do not trust anyone else. It is not so large as to not cut or accidentally released hundreds of thousands of credit card numbers or personal information of customers. We all know what happened.
However, if everyone is running their online business with integrity, I?m pretty sure that the volume of online business literally doubled in a very short time. Oh, of course, doubles as well, but it will be much faster. As the author of the article online, you can consider this as this is the main sub-themes related to the topic of Internet companies, one of them, you have to write. Yes, the subject is almost endless, but you need some ideas to get you started in your writing, so you can make a positive difference.
Consider, if you want every business in the real world, at least part of your online business. Therefore, you can write an article or series of articles for all industries, but still in line pattern. You can have the best software, the best hardware, and the latest developments in mobile computing and mobile transactions. We can talk about advertising, marketing, social media and new ideas and concepts for new business.
Can you explain how one can create your own online business, what are the rules to be followed, and how to build your business to start ? as ethically conducted. You can tell them what to look for, how VAT works, how to accept credit cards online, and how to create a robust cybersecurity strategy to maintain. All these things are worthy statements and information that people need to know if you want to live from online business. Indeed I hope you will please consider all this while preparing quality content online about this topic.
Source: http://ateslilolitam.com/preparation-of-quality-items-on-line-internet-business.html
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When Katie Couric revealed Monday (Sept. 24) she had suffered from bulimia and aimed her show at inspiring girls to get healthy, it was the second time the TV show host put her name behind a health cause. More than a decade ago, Couric advocated for colon cancer screening, after her husband died of the disease.
Such celebrity involvement in public health issues can be valuable, researchers say, because it brings attention to health problems and spurs people to partake in screenings and other disease-preventing behaviors.
Celebrities are not experts, but they "often speak personally, and bring compelling authenticity to public discourse," Simon Chapman, a professor of public health at the University of Sydney in Australia, wrote in an opinion piece published Tuesday (Sept. 25) in the journal BMJ.
However, some argue there are drawbacks when celebrities voice their opinions on health issues.
"Celebrity status is fleeting," Geof Rayner, former chairman of the United Kingdom Public Health Association, writes in a counterpoint published in the same journal. While celebrities can boost public health campaigns, they "must tread a cautious path of support, because of the risk that the celebrity becomes the story," Rayner said.
"Some celebrities might help, but let?s not look for saviors, buoyed by the happy thought that the work is done when a celebrity is involved," Rayner said.
A more lasting solution may be public health campaigns that "bring together the lobbying power of thousands of ordinary people through the Internet," Rayner said.
It's true that celebrity involvement in health issues can be challenging, particularly if the celebrity presents misinformation about the topic, said Georges Benjamin, executive director at the American Public Health Association. This occurred when actress Jenny McCarthy got behind the anti-vaccine movement.
But on the whole, celebrities can be very helpful in a public health campaign, Benjamin said. He noted that when Couric promoted colon cancer screening ? even having her colonoscopy performed on air ? the publicity led to an increase in colon cancer screenings.
"The right celebrity on the right issue can make an enormous difference," Benjamin said.
Pass it on: Celebrities bring a boost to public health campaigns, but their engagement in health issues can have drawbacks.
Follow MyHealthNewsDaily on Twitter @MyHealth_MHND. We're also on Facebook & Google+.
Copyright 2012 MyHealthNewsDaily, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/celebs-speak-health-issues-experts-debate-143815315.html
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This is exactly where the on the web business venture begins.The ecommerce company plan is a program of action, without which nothing of true value can ever be achieved. The ecommerce business program will cover a number of capabilities from the style of the internet web site to the fulfillment service techniques every of these functions should be the greatest available with a heavy bias towards the client. The item, about which the entire ecommerce business plan will revolve, wil?
Ecommerce Business Program
This is where the on the internet organization venture begins.The ecommerce company strategy is a program of action, without which nothing of genuine value can ever be achieved. The ecommerce business program will cover a number of features from the style of the web web site to the fulfillment service techniques every of these characteristics ought to be the very best obtainable with a heavy bias towards the buyer. The item, around which the complete ecommerce business plan will revolve, will have to fulfill specific criteria in order to make the online venture a good results. These are:
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Ability to ship the item before you launch your online venture you ought to find out no matter whether the item can be shipped very easily. This is will a daunting process if the product is bulky or extremely fragile. If the client can not get the product swiftly and in tact, you will loose repeat consumers and word of mouth marketing.
Expense of delivery in equivalent manner heavier items will expense much more to deliver to the door step than lightweight items. The price of delivery is an essential factor that decides the buyer makes use of when deciding whether or not or not to get an item. Therefore, keep this cost as low as attainable.
Cost of the item several customers are attracted to the online shopping simply because they get a lot of of their favorite merchandise at an a lot lower expense than in the actual- stores. You need to have to preserve the cost at least ten percent less than what is available in the brick-and-mortar market.
Availability do you strategy to have a great stock of the product that you propose to sell or do you have a very good tie-up with some supplier(s) which can provide you with the product on the spot. If the product is not accessible very easily to the buyer following the payment is processed you will have an extremely unhappy customer.
Target market feel regardless of whether you require to address the needs of a certain age group, geographical area, or it is to be offered for all people, all more than the planet.
Payment options what kind of payment possibilities you are supplying will greatly influence the sale of your item.
All these and more will have to be taken care of appropriate at the beginning at the stage exactly where the ecommerce enterprise strategy is completed.
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Source: http://funclub24.com/2012/09/25/the-ecommerce-enterprise-strategy-a-plan-of-action/
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EA Sports has just launched its latest iteration of the hugely successful soccer franchise FIFA 13. The new version of FIFA has some nice new features over and above last year?s version but the most significant is the long overdue ability to play against your friends in an online multiplayer mode.
JOIN THE CLUB! Are you ready for the most authentic football game on the App Store? FIFA 13 is more realistic than ever ? with all the authenticity and innovation you?ve come to expect from the FIFA franchise. Matches come to life with groundbreaking graphics and the most responsive controls ever delivered on iOS.
Challenge friends and other football fans from all over the world with the all-new Online Multiplayer mode! For the first time ever! Compete with friends anytime, anywhere using Online Multiplayer. Rise to the top of the Leaderboards and use superstars like Messi and Benzema to crush your competitors around the world.
FIFA 13 offers some great soccer gaming features like teams from 30 of the top leagues in the world, 500 officially licensed teams with real player names, management modes and of course the long awaited multi-player. Unfortunately multi-player is done via EA?s own Origin service rather than Apple?s Game Centre but if it works well, who really cares.
FIFA 13 is a universal binary so works great on the iPhone, iPad and iPod touch and is compatible with the iPhone 3GS, iPhone 4, iPhone 4S, iPad, iPad 2, the new iPad, iPod touch 3 (16 GB and above), and iPod touch 4. EA claims that the best gaming experience will be on the iPhone 4S, iPad 2 or the new iPad; no mention of the iPhone 5 in the write up although they do claim it is compatible.
Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/cp_cedAQl2c/story01.htm
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ScienceDaily (Sep. 24, 2012) ? A receptor protein suppresses local invasion and metastasis of breast cancer cells, the most lethal aspect of the disease, according to a research team headed by scientists from The University of Texas MD Anderson Cancer Center.
Reporting in Nature Medicine, the team described using high-throughput RNA sequencing to identify the leukemia inhibitory factor receptor (LIFR) as a novel suppressor of breast cancer metastasis, the spread of the disease to other organs.
"Based on our findings, we propose that restoring the expression or the function of key metastasis suppressors like LIFR could be used to block breast cancer metastasis," said lead investigator Li Ma, Ph.D., assistant professor in MD Anderson's Department of Experimental Radiation Oncology.
"Lack of clinically proven prognostic markers and therapeutic agents for metastasis are major barriers for eradicating breast cancer deaths," Ma said. "Although many metastasis-promoting genes have been identified, they have not been translated into clinical practice. The exceptions are the HER2- and VEGF-targeting agents, which have shown measurable but moderate benefit in the clinic."
Only a few genes have been established as metastasis suppressors, Ma said, and many researchers believe that such genes play only a minor role in metastasis.
The investigators in this study, however, found that LIFR is "highly relevant in human tumors." While 94 percent of normal human breast tissues show high LIFR expression, LIFR is downregulated or lost in a significant fraction of patients with ductal carcinoma in situ (DCIS) or invasive breast cancer, and loss of LIFR closely correlates with poor clinical outcomes.
Protein works by activating Hippo cascade to throttle YAP Ma said one of the major findings of the study is that LIFR suppresses both the invasion and colonization steps of metastasis by activating the Hippo kinase cascade that leads to functional inactivation of the transcriptional co-activator YAP.
"The LIFR protein is highly relevant in human cancer because it is down-regulated in about 40 percent of human breast cancers and completely lost in nearly 10 percent," Ma said. "Remarkably, in our study of approximately 1,000 patients, we found that loss of the LIFR protein in non-metastatic stages I to III breast tumors is highly associated with poor metastasis-free, recurrence-free and overall survival outcomes."
Ma noted that this work was regarded by peer reviewers as "a ground-breaking contribution" because it:
* Challenges the dogma that metastasis-suppressor genes are only a small component of metastasis compared with metastasis-promoting genes;
* Is the first report of a cell membrane receptor that activates Hippo signaling and has a critical function in cancer; and
* Might have a significant impact on clinical practice.
Ma said information about LIFR in cancer in the literature is very scarce. But some small studies have reported that LIFR is also lost in colon cancer and liver cancer through a gene-silencing mechanism called hypermethylation.
"There are many directions of research that should be pursued," Ma said. "For example, in order to develop LIFR-based methods of treatment, we must further understand the mechanism of its function and regulation of its expression."
Ma added that her group is generating LIFR conditional knockout mice to determine whether genetic deletion of LIFR in the breast will lead to tumorigenesis and metastasis.
Co-authors with Ma are Dahu Chen and Peijing Zhang, P h.D., of MD Anderson's Department of Experimental Radiation Oncology; Yutong Sun, Ph.D., Yongkun Wei, Ph.D., Abdol Hossein Rezaeian, Hui-Kuan Lin, Ph.D., and Mien-Chie Hung, Ph.D., all of MD Anderson's Department of Molecular and Cellular Oncology; Julie Teruya-Feldstein, M.D., of Memorial Sloan-Kettering's Department of Pathology; Sumeet Gupta of the Whitehead Institute for Biomedical Research; and Han Liang, Ph.D., of MD Anderson's Department of Bioinformatics and Computational Biology.
Lin, Hung and Ma are also affiliated with the Cancer Biology Program, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston. Mien-Chie Hung is additionally affiliated with the Center for Molecular Medicine and the Graduate Institute of Cancer Biology at China Medical University.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/34Ui-KEfSXY/120924174956.htm
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PULLMAN, WASH. -- Colorado's passing game came alive Saturday. Did it ever.
Celebrating Saturday's come-from-behind 35-34 victory over Washington State is one thing. But the Buffaloes believe they can build upon the win throughout the season, even with more talented Pac-12 opponents looming ahead on the schedule.
The chemistry between CU junior quarterback Jordan Webb and his receivers appeared light years better than in the first three games.
"We've been working real hard together," Webb said.
The transfer from Kansas threw for 345 yards and two touchdowns on 29-of-42 passing with one interception. He completed passes to eight different receivers.
Those included redshirt freshman Nelson Spruce, who caught eight for 103 yards and a touchdown, junior tight end DaVaughn Thornton, who had five for 60 yards and sophomore wideout Tyler McCulloch, who caught five for 42. Also in the group, senior tight end Nick Kasa, the converted defensive end who began Colorado's rally with a 70-yard touchdown pass with 7 minutes, 6 seconds left.
Colorado scored two more touchdowns after Kasa's score. The Buffs had never led in the game until Webb scored on a 4-yard keeper with 11 seconds left.
"Coach Embree has been talking about simplifying things out there and just play ball," McCulloch said. "We felt the timing early. We were just trying to stay ahead of the chains."
Kasa's 70-yard touchdown reception in the fourth quarter was CU's longest ever to a tight end during the regular season. It was his first career TD.
"Oh, my God, I've been trying to get a touchdown for a long time," Kasa said. "I kind of lost in the lights. I told myself, 'I'm not dropping this.'"
Webb was sacked six times. But he was given enough time to come up with timely plays."
"We did a good job of protecting him," Spruce said. "It's just a matter of getting that timing right. He can make the throws."
Webb said it will be easier for the team to prepare for Saturday's home game against UCLA after the victory.
"I'm sure on Monday (in practice), guys will have a little more bounce in their step,' Webb said.
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When you are hurt or sick you need health insurance. The cost of paying it on your own can place you in great debt. Simply getting the basic coverage may not be enough depending on your circumstances. There are times in your life where it may be in your interest to increase your coverage to things like income protection insurance or get additional amounts to help pay for upcoming costs.
When two people form one union it can be a lot cheaper for the cost of the premiums if the family plan is taken into account. However, if both of you are working you will need to decide which company has the better option or if the cost will be cheaper to continue the coverage on separate policies.
The cost to have a child has skyrocketed. Most of the fees that people pay for are the standard doctor office visits, medication for prenatal vitamins, and testing to ensure that the new baby is healthy. This does not include the actual hospital delivery costs. These costs can include everything from the use of the room to regular standard care.
If you and your spouse alone are covered you need to make plans for the little one that is due to arrive. Most children often get sick as their immune systems build up a tolerance. They will also need to get immunization shots from the doctor and any routine checkups. These expenses will not be covered by your carrier if you have not added them on your policy.
If you are the sole business owner you make the decisions as to what goes on in the business day to day. There may be managers and others that report to you, but you are held responsible for the big financial decisions concerning the company. As you are a vital part of the company, you need to make sure that you have coverage that reflects this. Many owners do not have any type of coverage and when they become sick end up having to sell their company to pay for their bills.
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People need health insurance in order to pay for a potential sickness or accident. However, there are times in their lives when the standard policy may not be enough. This is when additional protection and coverage should be increased to reflect this and to help lower out-of-pocket costs.
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The articles of Mark Anderson have really met the needs of the users. He suggests them to visit Medicalinsurance.org for more information.
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Source: http://www.informationgateway.org/biggest-life-warrant-additional-health-insurance/
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Western Michigan University student Alenna Brown ,19, leaves with her new iPhone 5 in Kalamazoo, Mich. on Friday, Sept. 21, 2012. (AP Photo/The Kalamazoo Gazette, Mark Bugnaski) ALL LOCAL TV OUT; LOCAL TV INTERNET OUT
Western Michigan University student Alenna Brown ,19, leaves with her new iPhone 5 in Kalamazoo, Mich. on Friday, Sept. 21, 2012. (AP Photo/The Kalamazoo Gazette, Mark Bugnaski) ALL LOCAL TV OUT; LOCAL TV INTERNET OUT
NEW YORK (AP) ? The Verizon Wireless version of the iPhone 5, which went on sale Friday, comes with a secret and unexpected feature: it works on AT&T's network as well.
Confirming blog reports, The Associated Press found that the Verizon iPhone 5 accepts an AT&T "SIM card" ? a little chip that identifies a phone to a wireless network. The phone can then be active on AT&T's network.
It's the first time Verizon iPhones have been able to access AT&T's network without complicated hacking procedures. The feature may mean little to most buyers, since they're signing up for two years of Verizon service. But it does give them the option of switching carriers.
It's unclear whether the feature is intended and whether the phones will work with other carriers, such as T-Mobile USA. But Verizon Wireless spokeswoman Brenda Raney confirmed Saturday that the iPhone 5 models it's selling are "unlocked."
Last year, the first shipments of the Sprint iPhone 4S were unlocked and worked on AT&T, but Sprint later issued software updates that turned off that capability.
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